This report provides findings from the APEC PPSTI Workshop on Domestic Innovation Systems and Networks was held on 13-14 August 2018 in Port Moresby, Papua New Guinea. The underpinning motivation that inspired the workshop was the persistent constraints that Papua New Guinea faced in mainstreaming science and technology to be recognized as an important driver for economic and productivity growth. There have been barriers to effectively coordinate and integrate government, research institutions and industry into a system to advance a productive innovation landscape in PNG. The shared experiences from the workshop have led to the development of the Manual on Domestic Innovation Systems and Networks.