This report provides policy recommendations based on a one-day workshop held on 19 August 2019, in Puerto Varas, Chile to collect various views from relevant international organizations and share best practices in applying the APEC principles to not only sector-specific but also cross-cutting issues. The workshop aimed at promoting awareness on the APEC principles as a guideline for implementing effective regulatory reform; share member economies’ best practices in applying the APEC principles on sector-specific and cross-cutting issues; identify possible challenges and opportunities in implementing the APEC principles; and discuss ways to harmonize the APEC principles with economies’ right to regulate, and to improve the principles for better regulation.