The White Paper aims to take stock of existing policy and regulatory frameworks regarding the prevention and mitigation of microplastic in coastal aquaculture input chains in APEC region. A desk study and expert workshops involving 42 contributors from 12 APEC economies were carried to collect the required data and information to develop the paper. This White Paper found that there are almost negligible regulatory frameworks to monitor and prevent microplastics in APEC’s coastal aquaculture input chains. Public discourses and research related to the issues are also limited. This White Paper recommends the continuation of public discourses and research activities to support the development of a comprehensive policy related to microplastic issues in coastal aquaculture. The comprehensive policy could be used by APEC economies to develop their own regulatory measures to ensure and promote the safety of seafood products from coastal aquaculture of APEC region.