The global health crisis has profoundly impacted the tourism industry. Given the critical role of tourism in many economies, it is essential to increase the readiness and resiliency of tourism destination stakeholders in managing health crises. There is a pressing need for guidelines and reference materials to navigate and manage health crises in APEC economies, while also providing a basis for further research in tourism health crisis management. This handbook offers a systematic approach to managing health risks and crises that affect tourism, covering necessary organizational structures, accountabilities, policies, and procedures. The handbook also includes case studies from selected APEC economies to examine their health crisis management practices and develop a more comprehensive understanding of the phenomenon. The health crises have prompted tourism stakeholders to reconsider their business practices and adopt sustainable tourism approaches, in order to create a solid foundation for long-term success.