Vaccination remains one of the most cost-effective public health interventions available. The Vaccine Spotlight Report aims to share successful policies and programs that have been implemented in APEC member economies to enhance vaccine confidence, acceptance and uptake. The initiatives submitted by economies in the report reveal valuable lessons for bolstering vaccination programs across the APEC region, highlighting the value of continued collaboration between economies that face similar challenges in order to strengthen vaccination efforts, improve health and well-being, and ultimately, support the resilience of our region.