The report explores the critical role of digitalization in empowering micro, small, and medium-sized enterprises (MSMEs) and cooperatives within APEC economies. It highlights systemic barriers such as limited digital literacy, infrastructure gaps, and gender-specific challenges, offering actionable strategies to address them. Key insights stem from a two-day symposium that brought together policymakers, industry leaders, and MSME representatives to share best practices and foster collaboration. Discussions emphasized the transformative potential of digital financial services, e-commerce platforms, and sustainability-driven initiatives to enhance MSMEs' global market access. The report concludes with policy recommendations to strengthen capacity-building, promote gender inclusivity, and integrate sustainable practices, positioning MSMEs as pivotal drivers of economic growth and resilience across the Asia-Pacific region.